Key takeaways
- Cordycepin (3′-deoxyadenosine) is a nucleoside closely related to adenosine.
- It is characteristic of Cordyceps militaris, less so of O. sinensis.
- Content varies with strain, conditions and processing.
- Figures are only meaningful with a stated method and batch.
Cordycepin is the compound most closely associated with Cordyceps militaris. This article explains what it is, where it is found and how to read claims about it.
What is cordycepin?
Cordycepin is a nucleoside, chemically known as 3′-deoxyadenosine. It is very similar in structure to adenosine, differing by a single oxygen atom. It was first isolated from Cordyceps militaris in the mid-twentieth century.
Where is it found?
Cordycepin is characteristic of C. militaris, produced in both its fruiting bodies and mycelium. The Himalayan caterpillar fungus, Ophiocordyceps sinensis, is generally reported to contain little or none. This is one of the main chemical differences between the two. See Cordyceps militaris vs Ophiocordyceps sinensis.
How much?
Cordycepin content varies considerably with strain, growing conditions and processing. Some products quote cordycepin figures; these are only meaningful if the testing method and batch are stated. See Certificates of Analysis.
Extraction
Cordycepin is water-soluble, so it is drawn out by hot water extraction. See How Cordyceps Extracts Are Made.
For other Cordyceps compounds, see Cordyceps Compounds and Chemistry Explained.